Kyle Manzardo was 3-for-4 with a homer and four RBIs Thursday for the Cleveland Guardians, who overcame a blown save by All-Star closer Emmanuel Clase to beat the host Kansas City Royals, 7-4, in 10 innings in an Opening Day clash.Steven Kwan led off the 10th inning with the tie-breaking RBI double for the defending American League Central champion Guardians, who have won both their season openers under second-year manager Stephen Vogt.Manzardo began the Guardians’ comeback from a 3-0 deficit in the fourth, when he tripled and scored on a sacrifice fly by Jhonkensy Noel. Jose Ramirez lofted another sacrifice fly in the fifth before Manzardo greeted Angel Zerpa by hitting a two-run homer on the first pitch he saw in the sixth.The 24-year-old, who made his first Opening Day roster this season, added insurance with a two-out, two-run double off Sam Long (0-1) in the 10th.Paul Sewald earned the save with a perfect 10th.Kwan had two hits.Vinnie Pasquantino, who was questionable entering the game due to a right hamstring injury he suffered last Saturday, hit a three-run homer in the third before he began the Royals’ comeback by lacing a leadoff double against Clase (1-0) in the ninth.Salvador Perez followed with a single to send pinch-runner Freddy Fermin to third before Fermin trotted home on Michael Massey’s sacrifice fly to the track in right.